Prague was our first stop as part of our cruise down the Danube which took us to the City of Budapest. We only had 2 days in Prague so we did visit the typical "touristy" sights. Here's a short list of what I remember:

-Walk across the Charles Bridge. Great views, gothic towers, Baroque statues. About 700 years old!
-Prague Castle
-St. Vitus Cathedral
-Old Towne Square
-Old Towne Tower - Astronomical Clock
-Open air market. Originally food market, but now also tourist gifts
-Mala Strana neighborhood with cobble stoned streets, old buildings
-John Lennon wall
Tram is also good transportation; we did a lot of walking.
Prague is known for their love of beers so if your a fan definitely try a few!

Nancy